Adults with mild or moderate major depression, screened from outpatient practices using a two-question technique, will be randomized to receive either supplementation with omega-3 fatty acids eicosopentanoic acid (EPA, docodohexanaenoic acid (DHA), Vitamin B-12 and folate or standard treatment with fluoxitine. Response to treatment will be measured using the Patient Health Questionnaire 9 (PHQ-9) to assess level of depressed mood and the DYNAmic short form 36 metric (DYNA) to assess the impact on physical and emotional functioning one, three and six months later. This is an ongoing study. This study will be done in conjunction with The Maine Medical Center, and the outcomes of this study will be readied for publication.

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